Inhibition of key digestive enzymes related to hyperlipidemia and protection of liver-kidney functions by Cystoseira crinita sulphated polysaccharide in high-fat diet-fed rats

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• 作者：Amel Ben Gara^a ; ^e ; ^{bengara_amel@yahoo.fr} ; Rihab Ben Abdallah Kolsi^a ; Rim Chaaben^b ; Nadia Hammami^c ; Majed Kammoun^d ; Francesco Paolo Patti^e ; Abdelfattah El Feki^f ; Lotfi Fki^a ; Hafedh Belghith^g ; Karima Belghith^a
• 关键词：Polysaccharide ; Antioxidant activity ; Obesity ; Liver-kidney functions
• 刊名：Biomedicine & Pharmacotherapy
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：85
• 期：Complete
• 页码：517-526
• 全文大小：2341 K
• 卷排序：85

文摘

The objective of this current study was to investigate the possible hyperlipidemic and antioxidative effects of Cystoseira crinita sulfated polysaccharide (CCSP) in rats fed with a high-fat diet, exhibited an inhibitory activity on pancreatic lipase in vitro. In vivo administration of this extract to HFD-rats lowered body weight and potentially inhibited key enzymes of lipid metabolism and absorption as lipase activity in both plasma and small intestine, which led to a notable decrease of blood LDL- cholesterol (LDL-Ch) and triglycerides (TG) levels, and an increase in HDL-cholesterol (HDL-Ch) levels in HFD-rats. CCSP was also observed to protect the liver-kidney functions efficiently, by decreasing of aspartate transaminase (AST), alanine transaminase (ALT), lactate dehydrogenase (LDH) and Creatine phosphokinase (CPK) activities and creatinine, albumin, T-bilirubin, uric acid, and urea rates in plasma. The histological analysis of liver and kidney tissues further established the positive effect of CCSP.