Survival Advantage and Comparable Toxicity in Reduced-Toxicity Treosulfan-Based versus Reduced-Intensity Busulfan-Based Conditioning Regimen in Myelodysplastic Syndrome and Acute Myeloid Leukemia Patients after Allogeneic Hematopoietic Cell Transplantation

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• 作者：Ioanna Sakellari ; ^{bmt@gpapanikolaou.gr} ; Despina Mallouri ; Eleni Gavriilaki ; Ioannis Batsis ; Maria Kaliou ; Varnavas Constantinou ; Apostolia Papalexandri ; Chrysavgi Lalayanni ; Chrysanthi Vadikolia ; Anastasia Athanasiadou ; Evangelia Yannaki ; Damianos Sotiropoulos ; Christos Smias ; Achilles Anagnostopoulos
• 关键词：Allogeneic hematopoietic stem cell transplantation ; Myeloid malignancies ; Reduced-toxicity conditioning ; Reduced-intensity conditioning
• 刊名：Biology of Blood and Marrow Transplantation
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：23
• 期：3
• 页码：445-451
• 全文大小：645 K
• 卷排序：23

文摘

A treosulfan-based reduced-toxicity regimen, FluTreo, achieved favorable outcomes in medically infirm acute myeloid leukemia and/or myelodysplastic syndrome patients Outcomes were compared to a historical group that received a reduced intensity busulfan-based conditioning (FluBuATG) The FluTreo group achieved higher survival rates with low relapse mortality, similar toxicity and transplantation-related mortality FluTreo conditioning was the only independent factor associated with favorable survival rates