Synthesis of fluorine-substituted [2.2]paracyclophane-based carbene precursors for copper-catalyzed enantioselective boration of α,β-unsaturated ketones

详细信息    查看全文

• 作者：Linyong Wang^&dagger ; ; Meng Ye^&dagger ; ; Lei Wang ; Wenzeng Duan ; Chun Song ; ^{chunsong@sdu.edu.cn} ; Yudao Ma ; ^{ydma@sdu.edu.cn}
• 刊名：Tetrahedron: Asymmetry
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：28
• 期：1
• 页码：54-61
• 全文大小：753 K
• 卷排序：28

文摘

Fluorine-substituted [2.2]paracyclophane-based carbene precursors have been successfully synthesized and applied to copper-catalyzed asymmetric β-boration of α,β-unsaturated ketones. Fluorination of the planar chiral carbenes has a beneficial impact on the catalytic performance of the relevant complexes. A variety of chiral β-boryl ketones were obtained in excellent yields (up to 99%) and with high enantioselectivities (up to 99% ee).