Mitochondrial DNA in CSF distinguishes LRRK2 from idiopathic Parkinson's disease
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- 作者：Petar Podlesniya ; d ; Dolores Vilasb ; Peggy Taylore ; Leslie M. Shawf ; Eduard Tolosab ; c ; d ; Ramon Trullasa ; c ; d ; ramon.trullas@iibb.csic.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：mtDNA ; mitochondrial DNA ; ddPCR ; digital droplet PCR ; NMNC ; non-manifesting non-carriers (subjects who do not carry the LRRK2G2019S mutation and do not manifest Parkinson's disease) ; NMC ; non-manifesting carriers (subjects who carry the LRRK2G2019S mutation and do not manifest Parkinson's disease) ; LRRK2-PD ; subjects who carry the LRRK2G2019S mutation and have Parkinson's disease ; IPD ; subjects who have a confirmed clinical diagnosis of Parkinson's disease but do not carry the LRRK2G2019S mutati
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：94
- 期：Complete
- 页码：10-17
- 全文大小：765 K
文摘
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Parkinson's disease is associated with high CSF concentration of mitochondrial DNA in LRRK2G2019S mutation carriers.
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The concentration of mitochondrial DNA in CSF differentiates idiopathic from LRRK2-related Parkinson's disease.
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Idiopathic, but not LRRK2-related, Parkinson's disease is associated with low CSF concentration of α-synuclein.