Vesicular stomatitis virus-based vaccines expressing EV71 virus-like particles elicit strong immune responses and protect newborn mice from lethal challenges
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- 作者：Qin Yan1 ; Linjuan Wu1 ; Longyun Chen ; Yali Qin ; yqin@whu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Zishu Pan ; zspan@whu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Mingzhou Chen ; chenmz@whu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Vesicular stomatitis virus ; EV71 virus-like particles
- 刊名：Vaccine
- 出版年：2016
- 出版时间：29 July 2016
- 年：2016
- 卷：34
- 期：35
- 页码：4196-4204
- 全文大小：2310 K
文摘
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We generated rVSVs encoding P1 and 3CD of EV71.
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We produced and purified VLPs of EV71 from rVSVs.
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VLPs produced from rVSVs protected neonatal mice against lethal viral challenge.