Regulation of inositol 1,4,5-trisphosphate-induced Ca²⁺ release by reversible phosphorylation and dephosphorylation

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• 作者：Veerle V ; erheyden ; Benoit Devogelaere ; Ludwig Missiaen ; Humbert De Smedt ; Geert Bultynck ; Jan B. Parys
• 关键词：Inositol 1 ; 4 ; 5-trisphosphate ; Inositol 1 ; 4 ; 5-trisphosphate receptor ; Ca²⁺ signaling ; Protein kinase ; Protein phosphatase
• 刊名：Biochimica et Biophysica Acta (BBA)/Molecular Cell Research
• 出版年：2009
• 出版时间：June 2009
• 年：2009
• 卷：1793
• 期：6
• 页码：959-970
• 全文大小：529 K

文摘

The inositol 1,4,5-trisphosphate (IPb>3b>) receptor (IPb>3b>R) is a universal intracellular Ca²⁺-release channel. It is activated after cell stimulation and plays a crucial role in the initiation and propagation of the complex spatio-temporal Ca²⁺ signals that control cellular processes as different as fertilization, cell division, cell migration, differentiation, metabolism, muscle contraction, secretion, neuronal processing, and ultimately cell death. To achieve these various functions, often in a single cell, exquisite control of the Ca²⁺ release is needed. This review aims to highlight how protein kinases and protein phosphatases can interact with the IPb>3b>R or with associated proteins and so provide a large potential for fine tuning the Ca²⁺-release activity and for creating efficient Ca²⁺ signals in subcellular microdomains.