Carbon nanotubes for delivery of small molecule drugs

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• 作者：Bin Sheng Wong ; Sia Lee Yoong ; Anna Jagusiak ; Tomasz Panczyk ; Han Kiat Ho ; Wee Han Ang ; Giorgia Pastorin
• 关键词：AAS ; Atomic absorption spectroscopy ; AMB ; Amphotericin B ; BBB ; Blood brain barrier ; BCEC ; Brain capillary endothelial cells ; BSA ; Bovine serum albumin ; CDDP ; Cisplatin ; Ce6 ; Chlorin e6 ; CEA ; Carcinoembryonic antigen ; CHI ; Chitosan ; CNF ; Carbon nanofiber ; CNTs ; Carbon nanotubes ; CP ; Carboplatin ; CPT ; Camptothecin ; CT ; Catechin ; DAU ; Daunorubicin ; dC ; 2&prime ; 2&prime ; -Difluoro-2&prime ; -deoxycytidine ; DDS ; Drug delivery system ; DEX ; Dexamethasone ; DMAAM ; N-dimethylacrylamide ; DNA ; Deoxyribonucleic
• 刊名：Advanced Drug Delivery Reviews
• 出版年：December, 2013
• 年：2013
• 卷：65
• 期：15
• 页码：1964-2015
• 全文大小：8209 K

文摘

In the realm of drug delivery, carbon nanotubes (CNTs) have gained tremendous attention as promising nanocarriers, owing to their distinct characteristics, such as high surface area, enhanced cellular uptake and the possibility to be easily conjugated with many therapeutics, including both small molecules and biologics, displaying superior efficacy, enhanced specificity and diminished side effects. While most CNT-based drug delivery system (DDS) had been engineered to combat cancers, there are also emerging reports that employ CNTs as either the main carrier or adjunct material for the delivery of various non-anticancer drugs.

In this review, the delivery of small molecule drugs is expounded, with special attention paid to the current progress of in vitro and in vivo research involving CNT-based DDSs, before finally concluding with some consideration on inevitable complications that hamper successful disease intervention with CNTs.