Antibody repertoire development in fetal and neonatal piglets. XXIV. Hypothesis: The ileal Peyer patches (IPP) are the major source of primary, undiversified IgA antibodies in newborn piglets
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- 作者：John E. Butlera ; john-butler@uiowa.edu" class="auth_mail" title="E-mail the corresponding author ; Kristina Santiago-Mateob ; Nancy Wertza ; Xiuzhu Sunc ; Marek Sinkorad ; marek.sinkora@worldonline.cz" class="auth_mail" title="E-mail the corresponding author ; David L. Francisb
- 关键词：Germfree animals ; Ileal Peyers patches ; Immunoglobulin A ; Blind ileal loops
- 刊名：Developmental & Comparative Immunology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：65
- 期：Complete
- 页码：340-351
- 全文大小：1267 K
文摘
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Ileal Peyers patches (IPP) could be isolated in blind loops under germfree conditions.
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IPP are responsible for the initial non-diversified secretory IgA (SIgA) in the neonatal gut.
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Colonization with a probiotic flora failed to induce repertoire diversification in the IPP.
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Despite their isolation, lymphocytes in the IPP of isolated loops were activated.
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“Natural” SIgA provides first responder anti-bacterial defense for the neonatal gut.