Biphasic Ccl20 regulation by Toll-like receptor 9 through the activation of ERK-AP-1 and non-canonical NF-κB signaling pathways

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• 作者：Pujarini Dutta ; Atri Ta¹ ; Bhupesh Kumar Thakur¹ ; Nirmalya Dasgupta ; Santasabuj Das ; ^{santasabujdas@yahoo.com} ; ^{dasss@icmr.org.in}
• 关键词：IEC ; intestinal epithelial cells ; EC ; epithelial cells ; LTβR ; lymphotoxin β receptor ; ActD ; actinomycin D ; DC ; dendritic cells ; FAE ; follicle-associated epithelium ; PP ; Peyer's Patches ; ILF ; isolated lymphoid follicles ; TLR ; Toll-like receptor ; PRR ; pattern recognition receptor ; PAMP ; pathogen-associated molecular pattern ; PBMC ; peripheral blood mononuclear cells ; IBD ; inflammatory bowel disease ; DAI (DLM-1/ZBP-1) ; DNA-dependent activator of IFN-regulatory factors ; iDC ; immature human DCs ; MAPKs
• 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：1861
• 期：1
• 页码：3365-3377
• 全文大小：1992 K
• 卷排序：1861

文摘

Bacterial DNA induces Ccl20 in colonic epithelial cells. In the epithelium, Ccl20 induction is persistent, but is transient in hematopoietic cells. Biphasic Ccl20 regulation during early and late phases by distinct signaling pathways Late phase Ccl20 induction requires non-canonical NF-κB pathways and Ccl20 promoter shows RelB/p52 binding.