Age, scrapie status, PrP genotype and follicular dendritic cells in ovine ileal Peyer¡¯s patches

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• 作者：Giuseppe Marruchella ; Ciriaco Ligios ; Giovanni Di Guardo
• 关键词：Sheep ; Scrapie ; Follicular dendritic cells ; Ileal Peyer&rsquo ; s patches ; Age ; PrP genotype
• 刊名：Research in Veterinary Science
• 出版年：2012
• 出版时间：October, 2012
• 年：2012
• 卷：93
• 期：2
• 页码：853-856
• 全文大小：697 K

文摘

Follicular dendritic cells (FDCs) residing within ileal Peyer¡¯s patches (PPs) are of crucial relevance for sheep scrapie early pathogenesis and subsequent scrapie prion neuroinvasion. In this study, ileal PP follicles were significantly more numerous in lambs than in adult Sarda breed sheep, with significant differences being also found in lymphoid follicle area, perimeter and FDC density. Furthermore, PrPd deposition within ileal PPs and host¡¯s PrP genotype did not significantly influence these parameters. We conclude that age significantly affects FDC density in ileal PPs from Sarda breed ovines, independently from host¡¯s scrapie status and PrP genotype.