NIH 11082 produces anti-depressant-like activity in the mouse tail-suspension test through a delta-opioid receptor mechanism of action

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• 作者：Pattipati S. Naidu ; Aron H. Lichtman ; Carey C. Archer ; Everett L. May ; Louis S. Harris ; Mario D. Aceto
• 关键词：Delta-opioid ; Anti-depressant ; Naltrindole ; Tail-suspension test ; Naltrexone ; Nor-binaltorphimine hydrochloride (nor-BNI)
• 刊名：European Journal of Pharmacology
• 出版年：2007
• 出版时间：2 July 2007
• 年：2007
• 卷：566
• 期：1-3
• 页码：132-136
• 全文大小：280 K

文摘

The present study examined the effects of NIH 11082 ((−)-(1R,5R,9R)-5,9-dimethyl-2′-hydroxy-2-(6-hydroxyhexyl)-6,7-benzomorphan hydrochloride), a benzomorphan analogue, in the mouse tail-suspension, an assay used to detect anti-depressant agents. NIH 11082 significantly decreased immobility time during tail-suspension, with a comparable magnitude as the tricyclic anti-depressant desipramine. Importantly, NIH 11082 failed to elicit convulsions or other overt behavioral signs of toxicity. The delta-opioid receptor antagonist naltrindole (ADb>50b> = 2.0 mg/kg), but not the non-selective mu-opioid receptor antagonist naltrexone or the kappa-opioid receptor antagonist nor-BNI, blocked the effects of NIH 11082 in the tail-suspension test. These results reinforce the notion that delta-opioid receptor agonists can produce significant effects in a behavioral model used to screen anti-depressant drugs.