Live imaging of mitochondrial dynamics in CNS dopaminergic neurons in vivo demonstrates early reversal of mitochondrial transport following MPP+ exposure
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- 作者：April A. Dukesa ; b ; Qing Baia ; b ; Victor S. Van Laara ; b ; Yangzhong Zhoua ; b ; c ; Vladimir Ilina ; b ; Christopher N. Davida ; b ; d ; Zeynep S. Agime ; Joshua L. Bonkowskyf ; Jason R. Cannone ; Simon C. Watkinsg ; h ; Claudette M. St. Croixg ; i ; Edward A. Burtona ; b ; j ; k ; eab25@pitt.edu" class="auth_mail" title="E-mail the corresponding author ; Sarah B. Bermana ; b ; bermans@upmc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Parkinson's disease ; Mitochondrial dynamics ; MPP+ ; ; Zebrafish ; Live imaging
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：95
- 期：Complete
- 页码：238-249
- 全文大小：1888 K
文摘
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We generated transgenic zebrafish expressing florescent proteins in mitochondria.
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Mitochondrial transport was imaged in the axons of dopaminergic neurons in vivo.
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Developmental changes in transport correlated with axonal growth and synaptogenesis.
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MPP+ exposure caused a profound increase in retrograde transport.
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These changes in transport preceded all other signs of pathogenesis.
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