MEK Inhibitors Reverse Growth of Embryonal Brain Tumors Derived from Oligoneural Precursor Cells
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- 作者：Katarzyna Modzelewska1 ; Elena F. Boer1 ; Timothy L. Mosbruger1 ; Daniel Picard6 ; Daniela Anderson1 ; Rodney R. Miles2 ; Mitchell Kroll1 ; William Oslund1 ; Theodore J. Pysher3 ; 4 ; Joshua D. Schiffman1 ; 5 ; Randy Jensen1 ; Cicely A. Jette1 ; Annie Huang6 ; Rodney A. Stewart1 ; 7 ; rodney.stewart@hci.utah.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：pediatric brain tumors ; CNS-PNET ; zebrafish ; oligodendrocyte ; embryonal ; SOX10 ; OLIG2 ; RAS ; MAPK ; MEK inhibitors
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：25 October 2016
- 年：2016
- 卷：17
- 期：5
- 页码：1255-1264
- 全文大小：4189 K
文摘
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Subsets of CNS-PNETs express oligodendrocyte precursor cell genes SOX10 and OLIG2
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Activating NRAS/MAPK signaling in OPCs generates CNS-PNET-like tumors in zebrafish
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Cancer genomes of zebrafish and human NB-FOXR2 CNS-PNETs are highly conserved
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MEK inhibitors are identified as a potential treatment for oligoneural/NB-FOXR2 CNS-PNETs