A kidney-derived cell line (SK) of Scatophagus argus was developed.
A low-osmolarity-adapted SK cell line (SK-la) cultured in hypotonicity (150 mOsm).
Osmoregulation of SK, SK-la and CIK in medium (150, 300 and 450 mOsm) was studied.
Na-K-ATPase activities of SK, SK-la and CIK in anisotonicity were detected.
SK and SK-la showed stronger osmoregulatory capacity than CIK.