Spinal TRPC6 channels contributes to morphine-induced antinociceptive tolerance and hyperalgesia in rats

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• 作者：Hua Jin^a ; ^{jinghuakm@163.com} ; Ying-tong Sun^b ; Guang-qiong Guo^a ; Da-lin Chen^a ; Yu-jin Li^a ; Gao-peng Xiao^a ; Xin-nan Li^a
• 关键词：TRPC6 ; Morphine ; Tolerance ; Hyperalgesia
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：3 February 2017
• 年：2017
• 卷：639
• 期：Complete
• 页码：138-145
• 全文大小：2094 K
• 卷排序：639

文摘

TRPC6 inhibition attenuated morphine withdrawal-induced hyperalgesia. TRPC6 inhibition suppressed morphine tolerance. TRPC6 inhibition suppressed morphine-induced increased levels of CaMKIIα and nNOS. TRPC6 inhibition blocked morphine-induced neuroinflammation.