Generation of Induced Pluripotent Stem Cells from Adult Rhesus Monkey Fibroblasts

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• 作者：Haisong Liu ; Fangfang Zhu ; Jun Yong ; Pengbo Zhang ; Pingping Hou ; Honggang Li ; Wei Jiang ; Jun Cai ; Meng Liu ; Kai Cui ; Xiuxia Qu ; Tingting Xiang ; Danyu Lu ; Xiaochun Chi ; Ge Gao ; Weizhi Ji ; Mingxiao Ding ; Hongkui Deng
• 刊名：Cell Stem Cell
• 出版年：2008
• 出版时间：4 December 2008
• 年：2008
• 卷：3
• 期：6
• 页码：587-590
• 全文大小：1259 K

文摘

Summary

Induced pluripotent stem (iPS) cells can be generated from somatic cells by transduction with several transcription factors in mouse and human. However, direct reprogramming in other species has not been reported. Here, we generated monkey iPS cells by retrovirus-mediated introduction of monkey transcription factors OCT4, SOX2, KLF4, and c-MYC.