Identification of PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide) as an essential gene for colorectal cancer (CRCs) cells
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- 作者：Shangfeng Suna ; 1 ; shangfengsun@126.com" class="auth_mail" title="E-mail the corresponding author ; Shuguang Chenga ; 1 ; Yunxiao Zhua ; 1 ; Peng Zhanga ; pengzhangg@139.com" class="auth_mail" title="E-mail the corresponding author ; Ning Liub ; Tong Xuc ; Chao Sund ; Yanfeng Lve
- 关键词：siRNA ; small interfering RNA ; CRC ; colorectal cancer ; PRKDC ; Protein Kinase ; DNA-Activated ; Catalytic Polypeptide
- 刊名：Gene
- 出版年：2016
- 出版时间：10 June 2016
- 年：2016
- 卷：584
- 期：1
- 页码：90-96
- 全文大小：973 K
文摘
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Down-regulation of PRKDC reduced CRC cell proliferation/survival in CRC cells.
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Inducible knockdown of PRKDC inhibited tumor growth in vivo.
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PRKDC down-regulation induced apoptosis partially through inhibiting AKT activation.
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PRKDC expression is associated with overall survival in CRC patients.