Structural Basis of Alcohol Inhibition of the Pentameric Ligand-Gated Ion Channel ELIC

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• 作者：Qiang Chen¹ ; Marta M. Wells¹ ; ⁴ ; Tommy S. Tillman¹ ; Monica N. Kinde¹ ; Aina Cohen⁵ ; Yan Xu¹ ; ² ; ³ ; Pei Tang¹ ; ² ; ⁴ ; ⁶ ; ^{ptang@pitt.edu}
• 关键词：alcohols ; ethanol ; pore blocking ; ELIC ; pentameric ligand-gated ion channels
• 刊名：Structure
• 出版年：2017
• 出版时间：3 January 2017
• 年：2017
• 卷：25
• 期：1
• 页码：180-187
• 全文大小：2042 K
• 卷排序：25

文摘

n-Alcohols, including 2-bromoethanol (BrEtOH), inhibit the function of ELIC Crystal structures show BrEtOH-binding sites in the pore and the ECD of ELIC BrEtOH binding to the pore at the 6′ position dominates its inhibitory action