- 作者：Ayyaz Ali ; Yasir Abu-Omar ; Amit Patel ; Ahmad Y. Sheikh ; Ziad Ali ; Amber Saeed ; Asim Akhtar ; Thanos Athanasiou ; John Pepper
- 刊名：The Journal of Thoracic and Cardiovascular Surgery
- 出版年：2009
- 出版时间：February 2009
- 年：2009
- 卷：137
- 期：2
- 页码：334-341
- 全文大小：294 K
Objective
Homograft aortic valve replacement is associated with excellent clinical and hemodynamic outcomes. Valves are implanted predominantly by using 2 techniques: the freehand subcoronary technique or as an aortic root replacement. Our aim was to identify any difference in survival, durability, and clinical performance.Methods
Demographic, operative, and clinical data were obtained retrospectively through case-note review. All operations were performed by a single surgeon. Propensity score–adjusted analysis was used by developing a nonparsimonious logistic regression model for implantation with subcoronary versus root replacement. Actuarial survival and freedom from valve-related events were compared with Kaplan–Meier curves and multivariable proportional hazard Cox regression.
Results
Between January 1, 1991, and January 1, 2001, 215 patients underwent aortic valve replacement with a homograft. The subcoronary technique was used in 131 (61 % ) patients. Eighty-four (39 % ) patients underwent free-standing aortic root replacement. After propensity risk adjustment, the subcoronary implantation technique was associated with a decreased risk of 30-day death (adjusted odds ratio, 0.18; 95 % confidence interval, 0.06–0.34; P = .03). Technique of insertion was not an independent predictor of overall mortality during follow-up after adjustment (propensity adjusted hazard ratio, 0.35; 95 % confidence interval, 0.09–1.41; P = .18). There were no significant differences in 1- and 5-year actuarial survival, freedom from structural valve disease, endocarditis, or reoperation.
Conclusions
Both the subcoronary and root replacement techniques for homograft aortic valve replacement are associated with excellent midterm survival and clinical performance. Root replacement was associated with an increased risk of perioperative death after adjustment for covariates by using propensity analysis.