Serpin-5 regulates prophenoloxidase activation and antimicrobial peptide pathways in the silkworm, Bombyx mori
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- 作者：Junlan Lia ; Li Maa ; Zhe Linc ; Zhen Zouc ; zouzhen@ioz.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Zhiqiang Lua ; b ; zhiqiang.lu@nwsuaf.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Serpin ; Prophenoloxidase ; Antimicrobial peptide ; Silkworm
- 刊名：Insect Biochemistry and Molecular Biology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：73
- 期：Complete
- 页码：27-37
- 全文大小：2437 K
文摘
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BmSpn-5 expression is up-regulated in the fat body of silkworm Bombyx mori in response to bacterial infection.
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BmSpn-5 inhibits beads melanization, systemic melanization and PPO activation in the larval silkworm.
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BmSpn-5 down-regulates antimicrobial peptides gloverin-3, cecropin-D and -E expression after bacterial infection.
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BmSpn-5 forms covalent complexes with silkworm clip domain serine proteases BmHP6 and SP21 respectively.