A short-type peptidoglycan recognition protein from tongue sole (Cynoglossus semilaevis) promotes phagocytosis and defense against bacterial infection
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- 作者：Qing-lei Suna ; b ; c ; Li Suna ; b ; lsun@qdio.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Peptidoglycan recognition protein ; Cynoglossus semilaevis ; Agglutination ; Phagocytosis ; Antibacterial effects
- 刊名：Fish & Shellfish Immunology
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：47
- 期：1
- 页码：313-320
- 全文大小：1828 K
文摘
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CsPGRP-SC2 is a short peptidoglycan recognition protein with a zinc binding site.
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CsPGRP-SC2 was expressed in multiple tissues and stimulated by pathogen infection.
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rCsPGRP-SC2 exhibited zinc-dependent ability to bind and agglutinate bacteria.
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Binding of rCsPGRP-SC2 enhanced bacterial phagocytosis by host phagocytes.
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When present in vivo, rCsPGRP-SC2 inhibited bacterial invasion in host tissues.
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