Downregulation of Peptidylprolyl isomerase A promotes cell death and enhances doxorubicin-induced apoptosis in hepatocellular carcinoma
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- 作者：Shaobing Chenga ; b ; c ; Mengchao Luoa ; Chaofeng Dinga ; Chuanhui Penga ; Zhen Lva ; Rongliang Tonga ; Heng Xiaoa ; Haiyang Xiea ; Lin Zhoua ; Jian Wua ; b ; drwujian@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Shusen Zhenga ; c ; shusenzheng@zju.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：PPIA ; Peptidylprolyl isomerase A ; HCC ; hepatocellular carcinoma ; ELISA ; Enzyme linked immunosorbent assay ; Bcl-2 ; B-cell CLL/lymphoma 2 ; Bcl-xL ; BCL2-like 1
- 刊名：Gene
- 出版年：2016
- 出版时间：10 October 2016
- 年：2016
- 卷：591
- 期：1
- 页码：236-244
- 全文大小：1392 K
文摘
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We investigated the expression of PPIA in HCC tissues and HCC patients serum.
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The expression of PPIA was significantly increased in HCC patients, however in serum was down-regulated.
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Knockdown of PPIA sensitizes HCC cells to doxorubicin.
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PPIA could serve as a novel marker and therapeutic molecular target for HCC patients.