Early and Long-Term Impaired T Lymphocyte Immune Reconstitution after Cord Blood Transplantation with Antithymocyte Globulin

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• 作者：Nerea Castillo¹ ; ^{ncastillo@bst.cat} ; Irene Garcí ; a-Cadenas² ; Pere Barba³ ; Carme Canals¹ ; Cristina Dí ; az-Heredia⁴ ; Rodrigo Martino² ; Christelle Ferrà ; ⁵ ; Isabel Badell⁶ ; Izaskun Elorza⁴ ; Jorge Sierra² ; David Valcá ; rcel³ ; Sergio Querol¹
• 关键词：Lymphocyte recovery ; Antithymocyte globulin ; Umbilical cord blood transplantation
• 刊名：Biology of Blood and Marrow Transplantation
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：23
• 期：3
• 页码：491-497
• 全文大小：732 K
• 卷排序：23

文摘

We describe the different lymphocyte subsets kinetics (CD3+, CD4+, CD8+, CD19, and natural killer cells) after transplantation in umbilical cord blood recipients We studied the predictive factors for each lymphocyte subset recovery after single umbilical cord blood transplantation in adult and pediatric patients We report different factors that influenced lymphocyte subset recovery after cord blood transplantation: lower antithymocyte globulin dose, negative recipient cytomegalovirus serostatus, and younger patients We describe the incidence and types of opportunistic infections in the different periods after cord blood transplantation These results highlight the importance of optimizing the use of antithymocyte globulin in the conditioning regimen. Other factors, such as age and cytomegalovirus serostatus, also play a role that needs to be considered when designing new umbilical cord blood transplantation protocols to avoid infectious-related mortality