Neonatal exposure to SERMs disrupts neuroendocrine development and postnatal reproductive function through alteration of hypothalamic kisspeptin neurons in female rats
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- 作者：Ryohei Ichimuraa ; b ; c ; red0828@hotmail.co.jp" class="auth_mail" title="E-mail the corresponding author ; Miwa Takahashia ; Tomomi Morikawaa ; Kaoru Inouea ; Kazunori Kuwataa ; d ; e ; Kento Usudab ; Makoto Yokosukaf ; Gen Watanabeb ; Midori Yoshidaa
- 关键词：ARC ; arcuate nucleus ; AVPV ; anteroventral periventricular nucleus ; BW ; body weight ; CNS ; central nervous system ; CL ; corpora lutea ; EB ; estradiol benzoate ; EE ; 17α-ethynylestradiol ; FSH ; follicle-stimulating hormone ; GnRH ; gonadotropin-releasing hormone ; HE ; hematoxylin and eosin ; HPG ; hypothalamus-pituitary-gonadal ; IHC ; immunohistochemistry ; ISH ; in situ hybridization ; LH ; luteinizing hormone ; OVX ; ovariectomy ; PND ; postnatal day ; P4 ; progesterone ; SERMs ; selective estrogen receptor modulators
- 刊名：Neurotoxicology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：56
- 期：Complete
- 页码：64-75
- 全文大小：2368 K
文摘
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Neonatal exposure to SERMs could disrupts the development of kisspeptin neurons.
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Raloxifene diminish KiSS1 expression in the AVPV and following LH-surge induction.
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Tamoxifen cease estrous cycle and musculinize KiSS1 expression in the ARC.
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Tissue-specific estrogenic activity of SERMs may alters with tissue development.