5-HT₇ receptor-mediated fear conditioning and possible involvement of extracellular signal-regulated kinase

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• 作者：Kotaro Takeda ; Minoru Tsuji ; ^{mtsuji@iuhw.ac.jp} ; Kazuya Miyagawa ; Hiroshi Takeda
• 关键词：5-HT ; serotonin ; DR4004 ; 2a-[4-(4-phenyl-1 ; 2 ; 3 ; 6-tetrahydropyridyl)butyl]-2a ; 3 ; 4 ; -tetrahydrobenzo(c ; d)indol-2-(1H)-one ; ERK ; extracellular signal-regulated kinase 1/2 ; pERK ; phosphorylated ERK ; CS ; conditioned stimulus ; US ; unconditioned stimulus ; mRNA ; messenger RNA ; i.p. ; intraperitoneally ; ANOVA ; analysis of variance ; TrkB ; tropomyosin-related kinase B ; BDNF ; brain-derived neurotrophic factor
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：18 January 2017
• 年：2017
• 卷：638
• 期：Complete
• 页码：69-75
• 全文大小：1364 K
• 卷排序：638

文摘

Activation of 5-HT7 receptors is critical for emotional learning and memory. 5-HT7 receptor-mediated ERK signaling in the amygdala is involved in context- and tone-dependent fear memory. Hippocampal ERK signaling plays a reciprocal role to that in the amygdala in context-dependent fear memory.