Membrane Interactions of Natural Cyclic Lipodepsipeptides of the Viscosin Group

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• 作者：Niels Geudens^a ; ¹ ; Mehmet Nail Nasir^b ; ¹ ; Jean-Marc Crowet^b ; Jos M. Raaijmakers^c ; Krisztina Fehé ; r^a ; Tom Coenye^d ; José ; C. Martins^a ; Laurence Lins^b ; Davy Sinnaeve^a ; ^{davy.sinnaeve@ugent.be} ; Magali Deleu^b ; ^{magali.deleu@ulg.ac.be}
• 关键词：viscosin group ; cyclic lipodepsipeptide ; model membranes ; membrane permeabilization ; spectroscopy ; antimicrobial activity
• 刊名：Biochimica et Biophysica Acta (BBA) - Biomembranes
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：1859
• 期：3
• 页码：331-339
• 全文大小：898 K
• 卷排序：1859

文摘

First comparative study of antimicrobial activity and membrane interaction of the four principal viscosin group cyclic lipopeptides The lipopeptides induce vesicle permeabilization, but not fusion in PE/PG/cardiolipin model membranes Activity against Gram-positive bacteria and membrane permeabilization are affected by the Glu2/Gln2 structural variation, but not by the Leu5 stereochemistry The conformation of the lipopeptides is retained upon membrane insertion Lipopeptide insertion increases POPC bilayer fluidity and is impaired by cholesterol