Lipid peroxidation in cell death

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• 作者：Michael M. Gaschler^a ; Brent R. Stockwell^a ; ^b ; ^{BStockwell@columbia.edu}
• 关键词：Lipid oxidation ; Oxidation ; Peroxidation ; Antioxidant ; Ferroptosis ; Neurodegeneration
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：482
• 期：3
• 页码：419-425
• 全文大小：816 K
• 卷排序：482

文摘

Lipid peroxides are an important class of reactive oxygen species. Lipid peroxides can be synthesized in many contexts and are mediators of disease and death. Lipid peroxidation is a hallmark of ferroptosis, and emerging form of regulated cell death. Alzheimer’s disease is a neurodegenerative disease characatarized by lipid peroxidation. Many mechanisms exist to ameliorate the deleterious effects of lipid peroxidation.