Carcinogenic risk of emerging persistent organic pollutant perfluorooctane sulfonate (PFOS): A proposal of classification

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• 作者：Ricardo Arrieta-Cortes^a ; ^{rarrieta@cinvestav.mx} ; Paulina Farias^b ; ^{paulina.farias@insp.mx} ; Carlos Hoyo-Vadillo^a ; ^c ; ^{citocromo@cinvestav.mx} ; Mina Kleiche-Dray^a ; ^d ; ^{Mina.Kleiche@ird.fr}
• 关键词：PFCs ; PFOS ; Perfluorooctane sulfonate ; Carcinogenic risk ; IARC ; Genotoxicity ; Risk assessment ; Cancer
• 刊名：Regulatory Toxicology and Pharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：83
• 期：Complete
• 页码：66-80
• 全文大小：7622 K
• 卷排序：83

文摘

Average global levels are around 20–30 ng PFOS/mL in blood samples. Cohort occupational study shows increase in bladder cancer risk in exposed group. Rodent test shows that PFOS is a peroxisome proliferator, do not occur in humans. Inadequate evidence of carcinogenicity in humans and experimental animals. PFOS is a Group 3 agent (not classifiable as to its carcinogenicity to humans).