Substituted 5-benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: A new class of pestivirus inhibitors

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• 作者：Gerhard Puerstinger ; Jan Paeshuyse ; Piet Herdewijn ; Jef Rozenski ; Erik De Clercq and Johan Neyts
• 关键词：Imidazo[4 ; 5-c]pyridines ; Pestivirus inhibitors ; BVDV ; HCV ; Antiviral
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2006
• 出版时间：15 October 2006
• 年：2006
• 卷：16
• 期：20
• 页码：5345-5349
• 全文大小：126 K

文摘

A novel class of inhibitors of pestiviruses (5-substituted 2-phenyl-5H-imidazo[4,5-c]pyridines) is described. Modification of the substituent in position 5 resulted in analogues with high activity (EC₅₀ < 100 nM) and selectivity (SI > 1000) against the pestivirus BVDV (bovine viral diarrhea virus).