Elevated Diastolic Closing Margin Is Associated with Intraventricular Hemorrhage in Premature Infants

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• 作者：Christopher J. Rhee ; MD¹ ; ^{cjrhee@texaschildrens.org" class="auth_mail" title="E-mail the corresponding author} ; Jeffrey R. Kaiser ; MD ; MA¹ ; ² ; Danielle R. Rios ; MD¹ ; Kathleen K. Kibler ; CCP³ ; ⁴ ; ⁵ ; R. Blaine Easley ; MD³ ; ⁴ ; ⁵ ; Dean B. Andropoulos ; MD³ ; ⁴ ; ⁵ ; Marek Czosnyka ; PhD⁶ ; Peter Smielewski ; PhD⁶ ; Georgios V. Varsos ; PhD⁶ ; Craig G. Rusin ; PhD⁷ ; C. Heath Gauss ; MS⁸ ; D. Keith Williams ; PhD ; MPH⁸ ; Ken M. Brady ; MD³ ; ⁴ ; ⁵
• 关键词：arterial blood pressure ; cerebral blood flow ; critical closing pressure
• 刊名：The Journal of Pediatrics
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：174
• 期：Complete
• 页码：52-56
• 全文大小：413 K

文摘

To determine whether the diastolic closing margin (DCM), defined as diastolic blood pressure minus critical closing pressure, is associated with the development of early severe intraventricular hemorrhage (IVH).

Study design

A reanalysis of prospectively collected data was conducted. Premature infants (gestational age 23-31 weeks) receiving mechanical ventilation (n = 185) had ∼1-hour continuous recordings of umbilical arterial blood pressure, middle cerebral artery cerebral blood flow velocity, and PaCO₂ during the first week of life. Models using multivariate generalized linear regression and purposeful selection were used to determine associations with severe IVH.

Results

Severe IVH (grades 3-4) was observed in 14.6% of the infants. Irrespective of the model used, Apgar score at 5 minutes and DCM were significantly associated with severe IVH. A clinically relevant 5-mm Hg increase in DCM was associated with a 1.83- to 1.89-fold increased odds of developing severe IVH.

Conclusion

Elevated DCM was associated with severe IVH, consistent with previous animal data showing that IVH is associated with hyperperfusion. Measurement of DCM may be more useful than blood pressure in defining cerebral perfusion in premature infants.