Role of antibodies and IL17-mediated immunity in protection against pneumococcal otitis media
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- 作者：Marrit N. Habets1 ; Saskia van Selm1 ; Fred J. van Opzeeland ; Elles Simonetti ; Peter W.M. Hermans2 ; Marien I. de Jonge ; Dimitri A. Diavatopoulos ; dimitri.diavatopoulos@radboudumc.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：Otitis media ; Streptococcus pneumoniae ; Interleukin-17 ; Antibody ; Mucosal vaccination ; Pneumococcal surface protein A
- 刊名：Vaccine
- 出版年：2016
- 出版时间：21 November 2016
- 年：2016
- 卷：34
- 期：48
- 页码：5968-5974
- 全文大小：559 K
文摘
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Mucosal vaccination with PspA and CTB restricts pneumococcal colonization.
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Vaccination reduces influenza-virus induced pneumococcal otitis media.
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Protection was correlated with a balanced anti-PspA IgG1:IgG2a ratio.
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Vaccination induces a mucosal Th17 response against PspA.
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Mice deficient in IL-17 signaling were not protected by vaccination.