Polyunsaturated fatty acid biostatus, phospholipase A₂ activity and brain white matter microstructure across adolescence

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• 作者：Robert K. McNamara^a ; ^{mcnamar@ucmail.uc.edu} ; Philip R. Szeszko^b ; ^c ; ¹ ; ^{philip.szeszko@mssm.edu} ; Stefan Smesny^d ; ^{stefan.smesny@med.uni-jena.de} ; Toshikazu Ikuta^b ; ^c ; ² ; ^{tikuta@umail.iu.edu} ; Pamela DeRosse^b ; ^c ; ^{pderosse@NSHS.edu} ; Fré ; dé ; ric M. Vaz^e ; ^{f.m.vaz@amc.uva.nl} ; Berko Milleit^f ; ^{berko.milleit@med.uni-jena.de} ; Uta-Christina Hipler^f ; ^{christina.hipler@med.uni-jena.de} ; Cornelia Wiegand^f ; ^{C.Wiegand@med.uni-jena.de} ; Jana Hesse^f ; ^{jana.hesse@med.uni-jena.de} ; G. Paul Amminger^g ; ^{amminger@unimelb.edu.au} ; Anil K. Malhotra^b ; ^c ; ^{amalhotra@nshs.edu} ; Bart D. Peters^b ; ^c ; ^{petersbart@hotmail.com} ; ^{bpeters1@nshs.edu}
• 关键词：AD ; axial diffusivity ; CC ; corpus callosum ; DTI ; diffusion tensor imaging ; FA ; fractional anisotropy ; FADS ; fatty acid desaturase ; IFOF ; inferior fronto-occipital fasciculus ; ILF ; inferior longitudinal fasciculus ; LC-PUFAs ; long-chain polyunsaturated fatty acids ; RD ; radial diffusivity ; SLF ; superior longitudinal fasciculus ; WM ; white matter
• 刊名：Neuroscience
• 出版年：2017
• 出版时间：20 February 2017
• 年：2017
• 卷：343
• 期：Complete
• 页码：423-433
• 全文大小：627 K
• 卷排序：343

文摘

Physiological phospholipase A2 activity levels are associated with brain white matter microstructure across adolescence. Membrane docosahexaenoic acid concentration is associated with white matter microstructure across adolescence. White matter development may involve cleavage of docosahexaenoic acid from membrane phospholipids by phospholipase A2. Docosahexaenoic acid and phospholipase A2 may be implicated in myelin-related neurodevelopmental disorders.