The effects of RB101, a mixed inhibitor of enkephalin-catabolizing enzymes, on carrageenin-induced spinal c-Fos expression are completely blocked by β-funaltrexamine, a selective μ-opioid re

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• 作者：Le Guen ; St&eacute ; phanie ; Honor&eacute ; Prisca ; Catheline ; Gw&eacute ; naë ; lle ; Fourni&eacute ; -Zaluski ; Marie-Claude ; et. al.
• 关键词：c-Fos ; Spinal cord ; RB101 ; Carrageenin ; μ ; -Opioid receptor ; β ; -Funaltrexamine
• 刊名：Brain Research
• 出版年：1999
• 出版时间：July 10, 1999
• 年：1999
• 卷：834
• 期：1-2
• 页码：200-206
• 全文大小：710 K

文摘

We have demonstrated that pre-administered RB101 (40 mg/kg, i.v.), a mixed inhibitor of enkephalin-catabolizing enzymes, decreased spinal c-Fos expression induced 1 h and 30 min after intraplantar (i.pl.) carrageenin (41 % reduction, p<0.01). These effects were completely blocked by pre-administered β-funaltrexamine (10 mg/kg, i.v., 24 h prior to stimulation), a selective long-lasting μ-opioid receptor antagonist. In conclusion, these results clearly demonstrate that the effects of endogenous enkephalins on noxiously evoked spinal c-Fos expression are essentially mediated via μ-opioid receptors.