Synthesis, structural characterization, cytotoxic properties and DNA binding of a dinuclear copper(II) complex
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- 作者：B.J.M. Leite Ferreiraa ; P. Brandã ; oa ; pbrandao@ua.pt" class="auth_mail" title="E-mail the corresponding author ; M. Meirelesb ; Fá ; tima Martelc ; Ana Correia-Brancoc ; Diana M. Fernandesd ; T.M. Santosa ; V. Fé ; lixa ; e ; vitor.felix@ua.pt" class="auth_mail" title="E-mail the corresponding author
- 关键词：Dinuclear copper(II) complex ; Phenanthroline ; Adenine ; HeLa ; Caco-2 ; DNA-binding
- 刊名：Journal of Inorganic Biochemistry
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：161
- 期：Complete
- 页码：9-17
- 全文大小：1215 K
文摘
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Dicopper(II) adenine/phenanthroline complex (1) was synthesized.
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The structure was determined by single crystal X-ray diffraction.
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The complex 1 has remarkable IC50 values of 0.87 ± 0.06 μM (HeLa) and 0.44 ± 0.06 μM (Caco-2).
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The Cu(II) complex interacts with calf thymus DNA via the intercalation mode.