Damage of the endothelial glycocalyx in chronic kidney disease
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- 作者：Jan-Sö ; ren Padberga ; Anne Wiesingera ; Giovana Seno di Marcoa ; Stefan Reutera ; Alexander Grabnera ; Dominik Kentrupa ; Alexander Lukasza ; Hans Oberleithnerb ; Hermann Pavenstä ; dta ; Marcus Branda ; Philipp Kü ; mpersa ; philipp.kuempers@ukmuenster.de" class="auth_mail
- 关键词：Endothelial glycocalyx ; Chronic kidney disease ; Shedding ; Syndecan-1 ; Hyaluronan ; Atomic force microscopy ; 5/6 Nephrectomy ; Cardiovascular disease ; Atherosclerosis
- 刊名：Atherosclerosis
- 出版年：June 2014
- 年：2014
- 卷：234
- 期：2
- 页码：335-343
- 全文大小：1117 K
文摘
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We examine the influence of CKD on the atheroprotective endothelial glycocalyx.
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We show that CKD is paralleled by increased shedding of the eGC in humans.
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5/6-nephrectomy deteriorates nanomechanical properties of the eGC in rats.
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Glycocalyx damage might be a substantial factor for atherosclerosis in CKD patients.