Biological activity and structure dependent properties of cuprous iodide complexes with phenanthrolines and water soluble tris (aminomethyl) phosphanes

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• 作者：Radosł ; aw Starosta^a ; ^{starosta@wchuwr.pl"" rel=""nofollow} ; Kamila Stokowa^a ; Magdalena Florek^b ; Jarosł ; aw Kró ; l^b ; Agnieszka Chwił ; kowska^c ; Julita Kulbacka^c ; Jolanta Saczko^c ; Jacek Skał ; a^d ; Mał ; gorzata Jeż ; owska-Bojczuk^a
• 关键词：Copper(I) complexes ; Aminomethylphosphanes ; Antibacterial ; antifungal and anticancer activity ; Bovine serum albumin luminescence quenching ; pBluescsriptSK+ plasmid gel electrophoresis
• 刊名：Journal of Inorganic Biochemistry
• 出版年：2011
• 出版时间：August 2011
• 年：2011
• 卷：105
• 期：8
• 页码：1102-1108
• 全文大小：851 K

文摘

This paper presents the biological activity of copper(I) iodide complexes with 1,10-phenanthroline (phen) or 2,9-dimethyl-1,10-phenanthroline (dmp) and three tris (aminomethyl) phosphanes: P(CH₂N(CH₂CH₂)₂NCH₃)₃ (1), P(CH₂N(CH₂CH₂)₂O)₃ (2) and P (CH₂N(CH₃)CH₂CH₂OH)₃ (3). Crystallographic and DFT data indicate a significantly stronger binding ability of 3 in the complexes [CuI (phen) P (CH₂N (CH₃)CH₂CH₂OH)₃] (3P) and [CuI(dmp)P(CH₂N(CH₃)CH₂CH₂OH)₃] (3N) in comparison to the 1 or 2 ligands. Most probably, this is caused by the relatively small steric requirements of 3. The complexes with dmp exhibit a very high in vitro activity against the Staphylococcus aureus strain (MIC — minimal inhibitory concentration: 2.5–5 μg/mL) and Candida albicans diploid fungus (MIC: 1.25–2.5 μg/mL). All the tested complexes also show a strong in vitro antitumor activity against human ovarian carcinoma cell lines: MDAH 2774 (IC₅₀: 7–2 μM) and cisplatin-resistant SCOV 3 (IC₅₀: 3–2 μM). Interestingly, the complexes with dmp of higher biological activity more weakly interact with bovine serum albumin (BSA) and less efficiently cleave the pBluescriptSK+ plasmid.