Identification and functional analysis of dual-specificity MAP kinase phosphatase 6 gene (dusp6) in response to immune challenges in Japanese flounder Paralichthys olivaceus

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• 作者：Shuo Li^a ; ¹ ; ^{shuo76@yahoo.com} ; Weijiao Peng^a ; Gaixiang Hao^a ; Jiafang Li^a ; Xuyun Geng^b ; Jinsheng Sun^a ; ^{jssun1965@aliyun.com}
• 关键词：Mitogen-activated protein kinase phosphatases ; Dusp6 ; Immune challenge ; Proinflammatory cytokine ; Paralichthys olivaceus
• 刊名：Fish & Shellfish Immunology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：60
• 期：Complete
• 页码：411-419
• 全文大小：1760 K
• 卷排序：60

文摘

Dual-specificity MAP kinase phosphatase 6 gene (PoDusp6) was identified from Paralichthys olivaceus. PoDusp6 is a constitutively expressed cytoplasmic protein. PoDusp6 expression was modulated by PAMPs and bacterial challenges. Overexpression of PoDusp6 led to a significant down-regulation of proinflammatory cytokines and Mx gene expression. Inhibition of PoDusp6 activity resulted in decreased IL-1beta gene expression induced by LPS in the HKMs.