Oral administration of nano-titanium dioxide particle disrupts hepatic metabolic functions in a mouse model

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• 作者：Julin Yang^a ; Min Luo^b ; Zhen Tan^b ; Manyun Dai^b ; Minzhu Xie^b ; Jiao Lin^b ; Huiying Hua^b ; Qing Ma^b ; Jinshun Zhao^b ; Aiming Liu^b ; ^{liuaiming@nbu.edu.cn}
• 关键词：ALP ; alkaline phosphatase ; ALT ; alanine aminotransferase ; AST ; aspartate aminotransferase ; BUN ; blood urea nitrogen ; CYP ; cytochrome P450 ; DBIL ; direct bilirubin ; GAPDH ; glyceraldehyde 3-phosphate dehydrogenase ; IBIL ; indirect bilirubin ; IL-6 ; interleukin 6 ; LDH ; lactate dehydrogenase ; Mrp ; multidrug resistance-related protein ; OATP ; bile salt export pump ; OSTB ; organic solute-transporter-β ; Q-PCR ; Quantitative polymerase chain reaction ; TBA ; total bile acid ; TiO2 NP ; TiO2 nano-particle ; TNFα ; t
• 刊名：Environmental Toxicology and Pharmacology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：49
• 期：Complete
• 页码：112-118
• 全文大小：1936 K
• 卷排序：49

文摘

Orally administered TiO2 NP deposits in cytoplasm of hepatocytes and disrupts liver metabolism function. Metabolism assay is a sensitive approach to test toxicity potential of Nano-TiO2. Dose-response relationship revealed help risk analysis and regulation of Nano-TiO2.