Phosphoinositide 3-kinase γ ties chemoattractant- and adrenergic control of microglial motility

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• 作者：Nadine Schneble^a ; ^{Nadine.Schneble@med.uni-jena.de} ; Caroline Schmidt^a ; ^{Caroline.Schmidt@med.uni-jena.de} ; Reinhard Bauer^a ; ^{Reinhard.Bauer@med.uni-jena.de} ; Jö ; rg P. Mü ; ller^a ; ^{Joerg.Mueller2@med.uni-jena.de} ; Shamci Monajembashi^b ; ^{shamci@fli-leibniz.de} ; Reinhard Wetzker^a ; ^{Reinhard.Wetzker@uni-jena.de}
• 关键词：Akt ; protein kinase Akt/PKB ; ATP ; Adenosine triphosphate ; C5a ; complement system component 5a ; C5aR ; complement system component 5a receptor ; cAMP ; Cyclic adenosine monophosphate ; DAPI ; 4&prime ; 6-diamidino-2-phenylindole ; HRP ; horseradish peroxidase ; PIP3 ; phosphatidylinositol (3 ; 4 ; 5)-trisphosphate ; shRNA ; small hairpin RNA
• 刊名：Molecular and Cellular Neuroscience
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：78
• 期：Complete
• 页码：1-8
• 全文大小：893 K
• 卷排序：78

文摘

PI3Kγ controls microglial migration induced by C5a and other chemoattractants. PI3Kγ driven microglial migration is suppressed by norepinephrine. Norepinephrine blocks lipid kinase activity of PI3Kγ.