刊名:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
出版年:2017
出版时间:January 2017
年:2017
卷:1864
期:1
页码:89-100
全文大小:2994 K
卷排序:1864
文摘
AKT-dependent phosphorylation of Ser22 located within the SAM domain induces oligomerization. Oligomeric CNK1 increases affinity to AKT. Oligomerization of CNK1 activates CNK1-mediated signaling. A phosphomimetic mutant at Thr8 counteracts stimulation of CNK1 by Ser22 phosphorylation. CNK1-S22F found in human tumors is a gain-of-function mutant.