Resolvin D1 down-regulates CYP1A1 and PTGS2 gene in the HUVEC cells treated with benzo(a)pyrene
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- 作者：Joanna Gdula-Argasińskaa ; jargasinska@cm-uj.krakow.pl" class="auth_mail" title="E-mail the corresponding author ; Jacek Czepielb ; Justyna Totoń-Żurańskac ; d ; Artur Jurczyszyne ; Paweł Wołkowc ; d ; Tadeusz Librowskia ; William Peruckif
- 关键词：AhR ; aryl hydrocarbon receptor ; BaP ; benzo(a)pyrene ; Bbf ; benzo(b)fluoranthene ; Bkf ; benzo(k)fluoranthene ; COX-2 ; cyclooxygenase-2 ; cPGES ; cytosolic prostaglandin E2 synthase ; CYP1A1 ; cytochrome P450 1 A1 ; DHA ; docosahexaenoic acid ; FA ; fatty acids ; GSTM1 ; gluthathione S transferase Mu1 ; NF-κB ; nuclear factor κB ; Nrf2 ; nuclear factor (erythroid-derived 2)-like 2 ; PAHs ; polycyclic aromatic hydrocarbons ; PLA2G4A ; phospholipase A2 IV ; PPARs ; peroxisome proliferator activated receptors ; PTGS2 ; prost
- 刊名：Pharmacological Reports
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：68
- 期：5
- 页码：939-944
- 全文大小：723 K
文摘
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Environmental stresses, genetic factors, diet and lifestyle can accentuate atheroma formation.
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HUVEC cells co-treated with BaP and RvD1 had a decrease of COX-2 and cPGES expression.
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Incubation with BaP and RvD1 resulted in repression of the PTGS2 and CYP1A1 gene.
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Our data suggested that RvD1 might potentially aid in the repair of the injured endothelium.