Repetitive acute intermittent hypoxia increases growth/neurotrophic factor expression in non-respiratory motor neurons
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- 作者：I. Satriotomo ; § ; ; satriotomo@ufl.edu" class="auth_mail" title="E-mail the corresponding author ; N.L. Nichols&dagger ; ; E.A. Dale&Dagger ; ; A.T. Emery ; J.M. Dahlberg ; G.S. Mitchell§ ;
- 关键词：AIH ; acute intermittent hypoxia ; BDNF ; brain-derived neurotrophic factor ; dAIH ; daily AIH ; HIF-1α ; hypoxia-inducible factor-1α ; IH ; intermittent hypoxia ; NTRK2 ; Neurotrophic Tyrosine Kinase Receptor 2 ; pLTF ; phrenic long-term facilitation ; pMF ; phrenic motor facilitation ; pTrkB ; phosphorylated TrkB ; rAIH ; repetitive acute intermittent hypoxia ; TrkB ; tropomyosin receptor kinase B ; VEGF ; vascular endothelial growth factor
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：13 May 2016
- 年：2016
- 卷：322
- 期：Complete
- 页码：479-488
- 全文大小：2325 K
文摘
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3 × wAIH is a modest protocol of chronic intermittent hypoxia (CIH).
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rAIH enhances BDNF and VEGF and its high-affinity receptors in non-respiratory motor neurons.
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rAIH induces transcription factor HIF-1α in spinal motor neurons.
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rAIH may restore lost motor function, such as spinal injury and motor neuron disease.