Distribution of Marburg virus in Africa: An evolutionary approach
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- 作者：Gianguglielmo Zehendera ; gianguglielmo.zehender@unimi.it" class="auth_mail" title="E-mail the corresponding author ; Chiara Sorrentinoa ; Carla Veoa ; Lisa Fiaschia ; Sonia Gioffrè ; a ; Erika Ebranatia ; Elisabetta Tanzib ; Massimo Ciccozzic ; Alessia Laia ; Massimo Gallia
- 关键词：Marburg virus ; Ravn virus ; Geographic dispersion ; Phylodynamics
- 刊名：Infection, Genetics and Evolution
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：44
- 期：Complete
- 页码：8-16
- 全文大小：1008 K
文摘
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The estimated evolutionary rate of the whole Marburg virus genome is 3.3 × 10− 4 substitutions/site/year.
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Bayesian analysis suggests that the MARV strain most probably originated in Uganda about 177.9 years ago.
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It also suggests that the RAVV strain originated in an area between Uganda and Kenya about 33.8 years ago.
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Our data indicates Uganda as the cradle of the Marburg virus in Africa.