Erythromycin and ethylparaben were rapidly eliminated within 2 min at low O3 doses. 5 Transformation products (TPs) were identified retaining the ERY lactone ring. EtP structural alterations took place at the ethyl ester chain yielding 15 TPs. Phytotoxicity can be attributed to the organic matter and its oxidation products. ERY- and EtP-resistant E. coli were eliminated after 15 min of ozonation.