Mechanistically Dissecting Autophagy: Insights from In Vitro Reconstitution
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- 作者：Livia Wilz Brier1 ; 2 ; Min Zhang1 ; 2 ; Liang Ge1 ; lge19830626@berkeley.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ER ; endoplasmic reticulum ; Atg ; autophagy-related gene ; PI3K ; phosphatidylinositol-3 kinase ; PI3P ; phosphatidylinositol-3 phosphate ; PE ; phosphatidylenthanolamine ; GUVs ; giant unilamellar vesicles ; ERGIC ; ER&ndash ; Golgi intermediate compartment ; SNARE ; soluble N-ethylmaleimide-sensitive factor attachment protein receptors ; LIR ; LC3 interaction motif ; AIM ; Atg8-interacting motif ; PI(4 ; 5)P2 ; phosphatidylinositol-4 ; 5-bisphosphate
- 刊名：Journal of Molecular Biology
- 出版年：2016
- 出版时间：8 May 2016
- 年：2016
- 卷：428
- 期：9
- 页码：1700-1713
- 全文大小：1349 K
文摘
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Autophagy is an essential cellular process for bulk turnover of cytoplasmic components.
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The mechanism of autophagic membrane assembly and cargo encapsulation is unclear.
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In vitro reconstitution advances our knowledge to the mechanism of autophagy.