Mg ++ requirement for MtHK binding, and Mg ++ stabilization of mitochondrial membranes via activation of MtHK & MtCK and promotion of mitochondrial permeability transition pore closure: A hypothesis on mechanisms underlying Mg ++’s antioxidant and cytoprotective effects
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- 作者：Shiva Golshani-Hebroni ; M.D. mechofmg@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ANT ; Adenine nucleotide translocator ; BB-CK ; brain type cytosolic isoenzyme of creatine kinase ; Ca ; ++ ; ; calcium ion ; Cr ; creatine ; CypD ; cyclophilin D ; CK ; creatine kinase ; G-6-P ; glucose-6-phosphate ; GF/PI3K/Akt ; Growth factor/Phosphoinositide-3-kinase/Protein kinase B ; GSK ; glycogen synthase kinase ; IPC ; ischemic preconditioning ; I/R ; ischemia/reperfusion ; MAM ; mitochondrial associated membrane ; MB-CK ; major cytosolic isoenzyme of creatine kinase in heart muscle ; Mg ; ++ ; ; ma
- 刊名：Gene
- 出版年：2016
- 出版时间：25 April 2016
- 年：2016
- 卷：581
- 期：1
- 页码：1-13
- 全文大小：772 K
文摘
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Magnesium ions have anti-oxidant, anti-necrotic, and anti-apoptotic effects.
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Mg ++ ions stabilize mitochondrial membranes via their action at: MtHK, MtCK, and PTP.
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Mg ++ ions also enhance cell survival via promoting Akt protein kinase activation.
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Magnesium/Calcium Hypothesis: Ca & Mg have antagonistic effects at MtHK, MtCK, & PTP.
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Proposal: Trial of Mg supplementation for cytopathies with elevated [Ca ++/Mg ++]i