Thymoquinone inhibits inflammation, neoangiogenesis and vascular remodeling in asthma mice
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- 作者：Xinming Su ; xinming_med@126.com" class="auth_mail" title="E-mail the corresponding author ; Yuan Ren ; Na Yu ; Lingfei Kong ; Jian Kang
- 关键词：Bronchial asthma ; Thymoquinone ; Ovalbumin ; VEGF/PI3K/Akt ; Slit-2 ; Robo-4
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：38
- 期：Complete
- 页码：70-80
- 全文大小：2470 K
文摘
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Thymoquinone (TQ) inhibits inflammation by antagonizing IL-4/− 5 in asthma mice.
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TQ suppresses the neovascularization and remodeling in vivo and in vitro.
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TQ inhibits VEGF through PI3K/AKT signaling pathway in vivo and in vitro.
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TQ up-regulates Slit-2 likely through the binding of Slit-2 and Robo-4.