Validation of an enantioselective analysis for (l)-pidolic acid by chiral gas chromatography with derivatization
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- 作者：John J. Salisburya ; john.j.salisbury@pfizer.com" class="auth_mail" title="E-mail the corresponding author ; Mingshu Lib ; Aisha Boydb
- 关键词：(l)-PCA ; l-pidolic acid ; (d)-PCA ; d-pidolic acid ; PCA ; pidolic acid ; (l)-PGA ; l-pyroglutamic acid ; (d)-PGA ; d-pyroglutamic acid ; PGA ; pyroglutamic acid ; TFAA ; trifluoroacetic anhydride ; HCl-IPA ; hydrochloride 2-propanol solution ; CPF ; chiral purity factor ; Wt ; weight
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：20 February 2016
- 年：2016
- 卷：120
- 期：Complete
- 页码：79-83
- 全文大小：430 K
文摘
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Enantiomeric purity determination of l-pidolic acid, a lactam of glutamic acid.
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Utilization of an efficient two-step achiral derivatization with GC analysis.
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Validation parameters included specificity, system precision, analyst repeatability, intermediate precision, accuracy, linearity, LOD/LOQ and solution stability.