SPARCL1 a novel player in cancer biology

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• 作者：Filippo Gagliardi^a ; ^{gagliardi.filippo@hsr.it}Author Vitae ; Ashwin Narayanan^bAuthor Vitae ; Pietro Mortini^aAuthor Vitae
• 关键词：SPARCL1 ; Hevin ; Matricellular proteins ; Cancer
• 刊名：Critical Reviews in Oncology/Hematology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：109
• 期：Complete
• 页码：63-68
• 全文大小：578 K
• 卷排序：109

文摘

Matricellular proteins are secreted, nonstructural proteins, involved in the mediation of molecular interactions between cells and extracellular microenvironment. They include several, structurally unrelated, members and their homologs. Among these a particularly interesting one is SPARCL1 due to its potential interactions in tumor biology.SPARCL1 is a secreted glycoprotein, belonging to SPARC family of matricellular proteins. It is implicated in the regulation of cell adhesion, migration, and proliferation. SPARCL1 is expressed in physiological context, both during embryogenesis and in adult life during tissue remodeling.Its diverse expression pattern in different forms of human cancers has suggested it may play different roles in tumor biology, as both oncogene and tumor suppressor, based on tumor type.Aim of this review is to critically revise current knowledges about the role, played by SPARCL1, in physiological and pathological contexts and highlight its role as a key-gene in the regulation of tumor biology.