Di-(2-ethylhexyl) phthalate could disrupt the insulin signaling pathway in liver of SD rats and L02 cells via PPARγ

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• 作者：Wang Zhang^a ; ¹ ; Xin -yue Shen^a ; ¹ ; Wen-wen Zhang^a ; ¹ ; Hao Chen^a ; Wei-ping Xu^b ; ^{xu_weiping666@163.com} ; Wei Wei^a ; ^{wwei@ahmu.edu.cn}
• 关键词：DEHP ; ROS ; Insulin resistance ; PPARγ ; Liver ; GLUT4
• 刊名：Toxicology and Applied Pharmacology
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：316
• 期：Complete
• 页码：17-26
• 全文大小：1700 K
• 卷排序：316

文摘

DEHP exacerbates insulin resistance both in liver tissues and cells. Expression of insulin receptor and GLUT4 were altered with PPARγ. DEHP can induce oxidative stress to disrupt the metabolic homeostasis. The dose of exposed DEHP is closed to daily exposure by human. Determine the key role of PPARγ to insulin resistance.